General Information
TriMix is a prescribed, injectable medication consisting of three active ingredients: alprostadil, papaverine and phentolamine. Together, these three medications help to relax, expand, and fill the corpus cavernosum (erectile tissue) with blood resulting in an erection shortly after administration. Unlike oral medications, TriMix is localized to the intended area rather than having to flow through the bloodstream into other areas of the body. TriMix is self-administered and easy to perform in the comfort of your own home.
Indications
TriMix is indicated in the treatment of males with erectile dysfunction. This injectable medication is for patients unsuitable for the oral medication prostaglandin E1.
Ingredients
What are the 3 medications that are combined to form this sterile injection?
-
Papaverine: This is a vasodilator, which helps to expand the blood vessels. When injected into the penile tissue, this medication causes the smooth muscles to relax. In turn, this allows blood to flow through the corpus cavernosum resulting in an erection.
-
Alprostadil: Also known as prostaglandin E1 (PGE1), alprostadil is a naturally occurring prostaglandin used as a medication. This medication is also within the vasodilator class. It, too, is used to help open the blood vessels by relaxing the smooth muscles within the penis. Alprostadil is listed on the World Health Organization’s List of Essential Medicines and was isolated in 1957 and approved for medical use in the United States in 1981.
-
Phentolamine: This medication is a reversible nonselective a-adrenergic antagonist. Its primary action is vasodilation. Because it is a nonselective a-blocker, this medication also increases cardiac output.
TriMix injection is a medication that is very customizable to the patient’s needs. In order to receive the most effective results, it is imperative that the patient, provider, and pharmacy work together in determining the correct formula. Be aware that it is possible that the first few administrations may not deliver the individual’s satisfactory result. Increasing the dosage little by little will help reach the individual patient’s goal. To do this, the initial dose should be 0.05cc (mL) to 0.2cc (mL) depending on the level of the patient’s ED. Max dose is 0.50cc (mL).
